YAP1 Status Defines Two Intrinsic Subtypes of LCNEC with Distinct Molecular Features and Therapeutic Vulnerabilities.

doi:10.1158/1078-0432.CCR-24-0361

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Article

YAP1 Status Defines Two Intrinsic Subtypes of LCNEC with Distinct Molecular Features and Therapeutic Vulnerabilities.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Oct 2024

Stewart C Allison, Diao Lixia, Xi Yuanxin, Wang Runsheng, Ramkumar Kavya, Serrano Alejandra G, Tanimoto Azusa, Rodriguez B Leticia, Morris Benjamin B, Shen Li, Zhang Bingnan, Yang Yan, Hamad Samera H, Cardnell Robert J, Duarte Alberto, Sahu Moushumi, Novegil Veronica Y, Weissman Bernard E, Frumovitz Michael, Kalhor Neda, Solis Soto Luisa, da Rocha Pedro, Vokes Natalie, Gibbons Don L, Wang Jing, Heymach John V, Glisson Bonnie, Byers Lauren Averett, Gay Carl M

Abstract excerpt

PURPOSE: Large cell neuroendocrine carcinoma (LCNEC) is a high-grade neuroendocrine malignancy that, like small cell lung cancer (SCLC), is associated with the absence of druggable oncogenic drivers and dismal prognosis. In contrast to SCLC, however, there is little evidence to guide optimal treatment strategies, which are often adapted from SCLC and non-small cell lung cancer approaches. EXPERIMENTAL DESIGN: To...

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Identifiers

PMID: 39150543
DOI: 10.1158/1078-0432.CCR-24-0361
PMCID: PMC11479841

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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