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In‐depth proteomic analysis reveals unique subtype‐specific signatures in human small‐cell lung cancer

1 Sept 2022

Abstract excerpt

BACKGROUND: Small-cell lung cancer (SCLC) molecular subtypes have been primarily characterized based on the expression pattern of the following key transcription regulators: ASCL1 (SCLC-A), NEUROD1 (SCLC-N), POU2F3 (SCLC-P) and YAP1 (SCLC-Y). Here, we investigated the proteomic landscape of these molecular subsets with the aim to identify novel subtype-specific proteins of diagnostic and therapeutic relevance....

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PMID: 36149789
DOI: 10.1002/ctm2.1060

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