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Article

Molecular phenotypes stratify small cell lung cancer for targeted therapy and immunotherapy.

British journal of cancer - 1 Jun 2026

Zhang Juxuan, Liu Yiyan, Yuan Hengrui, Zhan Ning, Deng Jiaxing, Tang Lefan, Li Xin, Liu Yixin, Zhao Wenyuan, Liu Shilong, Qi Lishuang

Abstract excerpt

BACKGROUND: Small cell lung cancer (SCLC), an aggressive neuroendocrine malignancy, exhibits high intertumoral heterogeneity and limited treatment options. Immune checkpoint inhibitors (ICIs) provide only modest benefits for SCLC, underscoring the need for clinically actionable phenotypes. METHODS: Consensus clustering of bulk transcriptomic data identified SCLC molecular phenotypes. Bulk and single-cell RNA...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41933195
DOI: 10.1038/s41416-026-03390-5
PMCID: PMC13184308

Genes

ANXA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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