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Article

Comparison of protein-based and genetic prognostic markers in a large cohort of primary pulmonary and extrapulmonary small cell neuroendocrine carcinoma.

Lung cancer (Amsterdam, Netherlands) - 1 Jul 2026

Pavlíčková Klára, Hojný Jan, Hájková Nikola, Waldauf Petr, Dundr Pavel, Drosslerová Marie, Švajdler Marián, Fabian Pavel, Stružinská Ivana, Krkavcová Eva, Dvořák Jiří, Michálková Romana, Zambo Iva Staniczková, Flídrová Miroslava, Laco Jan, Hornychová Helena, Delongová Patricie, Škarda Jozef, Hrudka Jan, Matěj Radoslav

Abstract excerpt

Small cell neuroendocrine carcinomas occur in both pulmonary (SCLC) and extrapulmonary sites (EP-SCNC). Although morphologically similar, they may differ biologically, but these differences are not well characterized. The aim of this study was to compare cohorts of SCLC (n = 215) and EP-SCNC(n = 184) with respect to molecular alterations, RNA and protein expression in tumor tissue. The median survival for SCLC...

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Source

Identifiers

PMID: 42217423
DOI: 10.1016/j.lungcan.2026.109466

Genes

KMT2D
TP53
ASCL1
NEUROD1
POU2F3
RB1
YAP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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