Single-cell RNA sequencing reveals tumor heterogeneity in small cell neuroendocrine cervical carcinoma

doi:10.1038/s42003-025-07605-y

Article

Single-cell RNA sequencing reveals tumor heterogeneity in small cell neuroendocrine cervical carcinoma

5 Feb 2025

Abstract excerpt

Small cell neuroendocrine cervical carcinoma (SCNECC) is an aggressive gynecological malignancy with poor prognosis. The precision therapeutic strategies for SCNECC are severely limited by the complex tumor microenvironment. Here, we mapped the single-cell landscape of a total of six samples from matched SCNECC cancerous foci and normal adjacent cervical tissues. Through analysis of 68,455 high-quality cells,...

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