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Protein Kinase D2 Modulates Cell Cycle By Stabilizing Aurora A Kinase at Centrosomes

17 Jul 2018

Abstract excerpt

Abstract Aurora A kinase (AURKA) is a master cell-cycle regulator that is often dysregulated in human cancers. Its overexpression has been associated with genome instability and oncogenic transformation. The protein kinase D (PKD) family is an emerging therapeutic target of cancer. Aberrant PKD activation has been implicated in tumor growth and survival, yet the underlying mechanisms remain to be elucidated. This...

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PMID: 30018032
DOI: 10.1158/1541-7786.mcr-18-0641

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