Article
Integrated molecular drivers coordinate biological and clinical states in melanoma.
Nature genetics - 1 Dec 2020
Conway Jake R, Dietlein Felix, Taylor-Weiner Amaro, AlDubayan Saud, Vokes Natalie, Keenan Tanya, Reardon Brendan, He Meng Xiao, Margolis Claire A, Weirather Jason L, Haq Rizwan, Schilling Bastian, Stephen Hodi F, Schadendorf Dirk, Liu David, Van Allen Eliezer M
Abstract excerpt
We performed harmonized molecular and clinical analysis on 1,048 melanomas and discovered markedly different global genomic properties among subtypes (BRAF, (N)RAS, NF1, triple wild-type (TWT)), subtype-specific preferences for secondary driver genes and active mutational processes previously unreported in melanoma. Secondary driver genes significantly enriched in specific subtypes reflected preferential...
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