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Characterizing the Mutational Landscape of In-Transit Melanoma Metastases.

Pigment cell & melanoma research - 1 Jul 2026

Camacho Luisa Quesada, El Moheb Mohamad, Mayhew Mackenzie M, Mercante Margaret G, Tocco Emily G, Kuchimanchi Nidhi, Kim Susan J, Cummins Kaelyn C, Dengel Lynn T, Tsung Allan, Slingluff Craig L, Fallahi-Sichani Mohammad, Witt Russell G

Abstract excerpt

In-transit melanoma (ITM) is a unique presentation of metastatic cutaneous melanoma associated with therapeutic challenges. Despite its clinical importance, the molecular drivers of ITM remain poorly defined. We aimed to characterize the mutational landscape of ITM and identify genetic alterations distinguishing it from other melanoma metastases. Tumor samples from 528 patients in the MSK-IMPACT dataset,...

Topics

Humans
Melanoma
Mutation
Skin Neoplasms
Neoplasm Metastasis
Membrane Proteins
Principal Component Analysis
GTP Phosphohydrolases

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Open in PubMed Open full text

Identifiers

PMID: 42449548
DOI: 10.1111/pcmr.70112
PMCID: PMC13369827

Genes

NRAS
IMPACT
NF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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