Genomic Classification of Cutaneous Melanoma.

Abstract excerpt

We describe the landscape of genomic alterations in cutaneous melanomas through DNA, RNA, and protein-based analysis of 333 primary and/or metastatic melanomas from 331 patients. We establish a framework for genomic classification into one of four subtypes based on the pattern of the most prevalent significantly mutated genes: mutant BRAF, mutant RAS, mutant NF1, and Triple-WT (wild-type). Integrative analysis...

Topics

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• Databases, Genetic
• BRAF gene
• KIT gene
• Melanoma
• Melanoma and MAPK Pathways
• Mutation