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Article

NF1-mutated melanoma tumors harbor distinct clinical and biological characteristics.

Molecular oncology - 1 Apr 2017

Cirenajwis Helena, Lauss Martin, Ekedahl Henrik, Törngren Therese, Kvist Anders, Saal Lao H, Olsson Håkan, Staaf Johan, Carneiro Ana, Ingvar Christian, Harbst Katja, Hayward Nicholas K, Jönsson Göran

Abstract excerpt

In general, melanoma can be considered as a UV-driven disease with an aggressive metastatic course and high mutational load, with only few tumors (acral, mucosal, and uveal melanomas) not induced by sunlight and possessing a lower mutational load. The most commonly activated pathway in melanoma is the mitogen-activated protein kinase (MAPK) pathway. However, the prognostic significance of mutational...

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Source

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Identifiers

PMID: 28267273
DOI: 10.1002/1878-0261.12050
PMCID: PMC5527484

Genes

BRAF
PTPN11
RASA2
RASSF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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