Genetic and Genomic Characterization of 462 Melanoma Patient-Derived Xenografts, Tumor Biopsies, and Cell Lines.

doi:10.1016/j.celrep.2017.10.052

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Article

Genetic and Genomic Characterization of 462 Melanoma Patient-Derived Xenografts, Tumor Biopsies, and Cell Lines.

Cell reports - 14 Nov 2017

Garman Bradley, Anastopoulos Ioannis N, Krepler Clemens, Brafford Patricia, Sproesser Katrin, Jiang Yuchao, Wubbenhorst Bradley, Amaravadi Ravi, Bennett Joseph, Beqiri Marilda, Elder David, Flaherty Keith T, Frederick Dennie T, Gangadhar Tara C, Guarino Michael, Hoon David, Karakousis Giorgos, Liu Qin, Mitra Nandita, Petrelli Nicholas J, Schuchter Lynn, Shannan Batool, Shields Carol L, Wargo Jennifer, Wenz Brandon, Wilson Melissa A, Xiao Min, Xu Wei, Xu Xaiowei, Yin Xiangfan, Zhang Nancy R, Davies Michael A, Herlyn Meenhard, Nathanson Katherine L

Abstract excerpt

Tumor-sequencing studies have revealed the widespread genetic diversity of melanoma. Sequencing of 108 genes previously implicated in melanomagenesis was performed on 462 patient-derived xenografts (PDXs), cell lines, and tumors to identify mutational and copy number aberrations. Samples came from 371 unique individuals: 263 were naive to treatment, and 108 were previously treated with targeted therapy (34),...

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Identifiers

PMID: 29141224
DOI: 10.1016/j.celrep.2017.10.052
PMCID: PMC5709812

Genes

BRAF
KIT
NRAS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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