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Article

Transitional B Cells in Early Human B Cell Development – Time to Revisit the Paradigm?

2 Dec 2016

Abstract excerpt

The B cell repertoire is generated in the adult bone marrow by an ordered series of gene rearrangement processes that result in massive diversity of immunoglobulin (Ig) genes and consequently an equally large number of potential specificities for antigen. As the process is essentially random, the cells exhibiting excess reactivity with self-antigens are generated and need to be removed from the repertoire before...

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PMID: 27994589
DOI: 10.3389/fimmu.2016.00546

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