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Article

Immunoglobulin heavy chain expression shapes the B cell receptor repertoire in human B cell development.

The Journal of clinical investigation - 1 Sept 2001

Meffre E, Milili M, Blanco-Betancourt C, Antunes H, Nussenzweig M C, Schiff C

Abstract excerpt

Developing B cells must pass a series of checkpoints that are regulated by membrane-bound Ig(mu) through the Igalpha-Igbeta signal transducers. To determine how Ig(mu) expression affects B cell development and Ab selection in humans we analyzed Ig gene rearrangements in pro-B cells from two patients who are unable to produce Ig(mu) proteins. We find that Ig(mu) expression does not affect V(H), D, or J(H) segment...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 11560957
DOI: 10.1172/JCI13051
PMCID: PMC200933

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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