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Article

Parkinson's disease-associated human ATP13A2 (PARK9) deficiency causes zinc dyshomeostasis and mitochondrial dysfunction.

Human molecular genetics - 1 Jun 2014

Park Jin-Sung, Koentjoro Brianada, Veivers David, Mackay-Sim Alan, Sue Carolyn M

Abstract excerpt

Human ATP13A2 (PARK9), a lysosomal type 5 P-type ATPase, has been associated with autosomal recessive early-onset Parkinson's disease (PD). ATP13A2 encodes a protein that is highly expressed in neurons and is predicted to function as a cation pump, although the substrate specificity remains unclear. Accumulation of zinc and mitochondrial dysfunction are established aetiological factors that contribute to PD;...

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PMID: 24399444
DOI: 10.1093/hmg/ddt623
PMCID: PMC4014187

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