Article

Structural basis of polyamine transport by human ATP13A2 (PARK9)

2021-05-28

Abstract excerpt

Polyamines are small, organic polycations that are ubiquitous and essential to all forms of life. Currently, how polyamines are transported across membranes is not understood. Recent studies have suggested that ATP13A2 and its close homologs, collectively known as P5B-ATPases, are polyamine transporters at endo-/lysosomes. Loss-of-function mutations of ATP13A2 in humans cause hereditary early-onset Parkinson’s dis...

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Literature Corpus work: 454c6141-2e93-5fce-8118-268f7ad79bff
DOI: 10.1101/2021.05.28.446245

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