Article
Temporal dynamics predict symptom onset and cognitive decline in familial frontotemporal dementia.
Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 May 2023
Whiteside David J, Malpetti Maura, Jones P Simon, Ghosh Boyd C P, Coyle-Gilchrist Ian, van Swieten John C, Seelaar Harro, Jiskoot Lize, Borroni Barbara, Sanchez-Valle Raquel, Moreno Fermin, Laforce Robert, Graff Caroline, Synofzik Matthis, Galimberti Daniela, Masellis Mario, Tartaglia Maria Carmela, Finger Elizabeth, Vandenberghe Rik, de Mendonça Alexandre, Tagliavini Fabrizio, Butler Chris R, Santana Isabel, Ber Isabelle Le, Gerhard Alexander, Ducharme Simon, Levin Johannes, Danek Adrian, Otto Markus, Sorbi Sandro, Pasquier Florence, Bouzigues Arabella, Russell Lucy L, Rohrer Jonathan D, Rowe James B, Rittman Timothy
Abstract excerpt
INTRODUCTION: We tested whether changes in functional networks predict cognitive decline and conversion from the presymptomatic prodrome to symptomatic disease in familial frontotemporal dementia (FTD). METHODS: For hypothesis generation, 36 participants with behavioral variant FTD (bvFTD) and 34 controls were recruited from one site. For hypothesis testing, we studied 198 symptomatic FTD mutation carriers, 341...
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