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Article

Antibody Isotype Switching as a Mechanism to Counter HIV Neutralization Escape

1 Nov 2020

Abstract excerpt

Neutralizing antibodies (nAbs) to highly variable viral pathogens show remarkable diversification during infection, resulting in an "arms race" between virus and host. Studies of nAb lineages have shown how somatic hypermutation (SHM) in immunoglobulin (Ig)-variable regions enables maturing antibodies to neutralize emerging viral escape variants. However, the Ig-constant region (which determines isotype) can also...

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PMID: 33238131
DOI: 10.1016/j.celrep.2020.108430

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