Article
Crosstalk between adipocytes and M2 macrophages compensates for osteopenic phenotype in the Lrp5-deficient mice.
Experimental biology and medicine (Maywood, N.J.) - 1 Mar 2021
Li Lisha, Qiu Xuemin, Zhang Na, Sun Yan, Wang Yan, Wang Ling
Abstract excerpt
A loss-of-function mutation in the Lrp5 gene in mice leads to a low bone mass disorder due to the inhibition of the canonical Wnt signaling pathway; however, the role of bone marrow microenvironment in mice with this mutation remains unclear. In this study, we evaluated proliferation and osteogenic potential of mouse osteoblasts using the MTT assay and Alizarin red staining. The levels of alkaline phosphatase,...
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