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Article

LRP5 regulates human body fat distribution by modulating adipose progenitor biology in a dose- and depot-specific fashion.

Cell metabolism - 3 Feb 2015

Loh Nellie Y, Neville Matt J, Marinou Kyriakoula, Hardcastle Sarah A, Fielding Barbara A, Duncan Emma L, McCarthy Mark I, Tobias Jonathan H, Gregson Celia L, Karpe Fredrik, Christodoulides Constantinos

Abstract excerpt

Common variants in WNT pathway genes have been associated with bone mass and fat distribution, the latter predicting diabetes and cardiovascular disease risk. Rare mutations in the WNT co-receptors LRP5 and LRP6 are similarly associated with bone and cardiometabolic disorders. We investigated the role of LRP5 in human adipose tissue. Subjects with gain-of-function LRP5 mutations and high bone mass had enhanced...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25651180
DOI: 10.1016/j.cmet.2015.01.009
PMCID: PMC4321886

Genes

LRP5
LRP6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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