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Article

Patients with high bone mass phenotype exhibit enhanced osteoblast differentiation and inhibition of adipogenesis of human mesenchymal stem cells.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Nov 2007

Qiu Weimin, Andersen Tom E, Bollerslev Jens, Mandrup Susanne, Abdallah Basem M, Kassem Moustapha

Abstract excerpt

UNLABELLED: Genetic mutations in the LRP5 gene affect Wnt signaling and lead to changes in bone mass in humans. Our in vivo and in vitro results show that activated mutation T253I of LRP5 enhances osteogenesis and inhibits adipogenesis. Inactivating mutation T244M of LRP5 exerts opposite effects. INTRODUCTION: Mutations in the Wnt co-receptor, LRP5, leading to decreased or increased canonical Wnt signaling,...

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Topics

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Share to Adipogenesis
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Low Density Lipoprotein Receptor-Related Protein-5

Share to Osteoblasts

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Share to Transduction, Genetic

Share to Wnt3 Protein

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Source

Identifiers

PMID: 17680723
DOI: 10.1359/jbmr.070721

Genes

LRP5
HBM
DKK1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Patients with high bone mass phenotype exhibit enhanced osteoblast differentiation and inhibition of adipogenesis of human mesenchymal stem cells.PMID 17680723Read ↗

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