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Article

High Bone Mass in Mice Expressing a Mutant <i>LRP5</i> Gene

1 Jun 2003

Abstract excerpt

A unique mutation in LRP5 is associated with high bone mass in man. Transgenic mice expressing this LRP5 mutation have a similar phenotype with high bone mass and enhanced strength. These results underscore the importance of LRP5 in skeletal regulation and suggest targets for therapies for bone disease. A mutation (G171V) in the low-density lipoprotein receptor related protein 5 (LRP5) has been associated with...

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Identifiers

PMID: 12817748
DOI: 10.1359/jbmr.2003.18.6.960

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