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Article

Pathogenic mutations and polymorphisms in the lipoprotein receptor-related protein 5 reveal a new biological pathway for the control of bone mass.

Current opinion in lipidology - 1 Apr 2005

Ferrari Serge L, Deutsch Samuel, Antonarakis Stylianos E

Abstract excerpt

PURPOSE OF REVIEW: This review summarizes recent findings concerning the genomic variations of the lipoprotein receptor-related protein 5 (LPR5) in relation to bone biology. RECENT FINDINGS: Mutations in the LRP5 gene causing high bone mass (HBM) and osteoporosis-pseudoglioma (OPPG) underscored the role of the Wnt-LRP5 canonical signaling on bone formation. Additional LRP5 activating mutations have been...

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Share to Bone Density
Share to Bone Diseases, Metabolic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Intercellular Signaling Peptides and Proteins

Share to LDL-Receptor Related Proteins

Share to Low Density Lipoprotein Receptor-Related Protein-5

Share to Polymorphism, Genetic

Share to Wnt Proteins

Source

Identifiers

PMID: 15767861
DOI: 10.1097/01.mol.0000162326.62419.e4

Genes

LRP5
HBM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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