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Article

LRP5 and bone mass regulation: Where are we now?

10 Jan 2012

Abstract excerpt

The discovery of causal mutations in the low-density lipoprotein receptor-related protein 5 (LRP5) gene underlying conditions of altered bone mass ushered in a new era in bone research. Since those original publications, the role of Lrp5 and the Wnt/β-catenin signaling pathway controlled by Lrp5 and its homologs, Lrp6 and Lrp4, in bone mass regulation has been an intense area of investigation. Studies to date...

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Identifiers

PMID: 23951413
DOI: 10.1038/bonekey.2012.1

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