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Article

The class A repeats of LRP5 are required for normal development of bone, retinal vasculature and mammary gland in vivo.

Disease models & mechanisms - 1 Nov 2025

Diegel Cassandra R, Michalski Megan N, Ubels John L, Wiartalla Gabrielle Foxa, Lin Cheng-Mao, Zhong Zhendong A, McDonald Mitchell J, Ethen Nicole J, Brookshire Madison, Madaj Zachary B, Xia Mingxuan, Gavine Paul R, Antonetti David A, Williams Bart O

Abstract excerpt

Low-density lipoprotein-related receptor 5 (LRP5) is an LDLR family member with well-defined roles in mediating Wnt signaling. Its domain structure includes four LDLR class B and three LDLR class A repeats. Class B repeats mediate binding with Wnt ligands and other effectors, while the role of the LRP5 class A repeats, known to interact with apolipoproteins within the LDLR, is unclear. Complete loss of the LRP5...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Low Density Lipoprotein Receptor-Related Protein-5

Share to Mammary Glands, Animal

Share to Mice, Inbred C57BL

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Source

Open in PubMed Open full text

Identifiers

PMID: 40932232
DOI: 10.1242/dmm.052280
PMCID: PMC12661645

Genes

LRP5
LDLR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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