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Using B cell receptor lineage structures to predict affinity

11 Nov 2020

Abstract excerpt

We are frequently faced with a large collection of antibodies, and want to select those with highest affinity for their cognate antigen. When developing a first-line therapeutic for a novel pathogen, for instance, we might look for such antibodies in patients that have recovered. There exist effective experimental methods of accomplishing this, such as cell sorting and baiting; however they are time consuming and...

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PMID: 33175831
DOI: 10.1371/journal.pcbi.1008391

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