Article

Using B cell receptor lineage structures to predict affinity

2020-04-25

Abstract excerpt

<h4>ABSTRACT</h4> We are frequently faced with a large collection of antibodies, and want to select those with highest affinity for their cognate antigen. When developing a first-line therapeutic for a novel pathogen, for instance, we might look for such antibodies in patients that have recovered. There exist effective experimental methods of accomplishing this, such as cell sorting and baiting; how-ever they are...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a7928021-91d1-5131-ba1a-962044374287
DOI: 10.1101/2020.04.24.060194

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Using B cell receptor lineage structures to predict affinityDOI 10.1101/2020.04.24.060194Read

Using B cell receptor lineage structures to predict affinitySemantic proximity Read

Structural diversity of B-cell receptor repertoires along the B-cell differentiation axis in humans and miceSemantic proximity Read

Advances in antibody discovery from human BCR repertoiresSemantic proximity Read

How repertoire data are changing antibody scienceSemantic proximity Read

Per-sample immunoglobulin germline inference from B cell receptor deep sequencing dataSemantic proximity Read

Structural Diversity of B-Cell Receptor Repertoires along the B-cell Differentiation Axis in Humans and MiceSemantic proximity Read

Combining mutation and recombination statistics to infer clonal families in antibody repertoires.Semantic proximity Read

Combining mutation and recombination statistics to infer clonal families in antibody repertoiresSemantic proximity Read

Integrated single-cell analyses of affinity-tested B-cells enable the identification of a gene signature to predict antibody affinitySemantic proximity Read

Inferring B cell phylogenies from paired heavy and light chain BCR sequences with DowserSemantic proximity Read

RAbHIT: R Antibody Haplotype Inference ToolSemantic proximity Read

The influence of the phylogenetic inference pipeline on murine antibody repertoire sequencing data following viral infectionSemantic proximity Read