Article
Cholecystokinin 1 receptor activation restores normal mTORC1 signaling and is protective to Purkinje cells of SCA mice.
Cell reports - 12 Oct 2021
Wozniak Emily A L, Chen Zhao, Paul Sharan, Yang Praseuth, Figueroa Karla P, Friedrich Jill, Tschumperlin Tyler, Berken Michael, Ingram Melissa, Henzler Christine, Pulst Stefan M, Orr Harry T
Abstract excerpt
Spinocerebellar ataxias (SCAs) are a group of genetic diseases characterized by progressive ataxia and neurodegeneration, often in cerebellar Purkinje neurons. A SCA1 mouse model, Pcp2-ATXN1[30Q]D776, has severe ataxia in absence of progressive Purkinje neuron degeneration and death. Previous RNA-seq analyses identify cerebellar upregulation of the peptide hormone cholecystokinin (Cck) in Pcp2-ATXN1[30Q]D776...
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