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Article

Pruning and loss of excitatory synapses by the parkin ubiquitin ligase.

Proceedings of the National Academy of Sciences of the United States of America - 9 Dec 2008

Helton Thomas D, Otsuka Takeshi, Lee Ming-Chia, Mu Yuanyue, Ehlers Michael D

Abstract excerpt

Mutations in the PARK2 gene cause hereditary Parkinson disease (PD). The PARK2 gene product, termed parkin, is an E3 ubiquitin ligase that mediates the transfer of ubiquitin onto diverse substrate proteins. Despite progress in defining the molecular properties and substrates of parkin, little is...

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Identifiers

PMID: 19033459
DOI: 10.1073/pnas.0802280105
PMCID: PMC2614788

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19033459-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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