Article
Cellular Reprogramming-A Model for Melanoma Cellular Plasticity.
International journal of molecular sciences - 5 Nov 2020
Granados Karol, Poelchen Juliane, Novak Daniel, Utikal Jochen
Abstract excerpt
Cellular plasticity of cancer cells is often associated with phenotypic heterogeneity and drug resistance and thus remains a major challenge for the treatment of melanoma and other types of cancer. Melanoma cells have the capacity to switch their phenotype during tumor progression, from a proliferative and differentiated phenotype to a more invasive and dedifferentiated phenotype. However, the molecular...
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