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Connecting the dots: Melanoma cell of origin, tumor cell plasticity, trans‐differentiation, and drug resistance

3 May 2023

Abstract excerpt

Melanoma, a lethal malignancy that arises from melanocytes, exhibits a multiplicity of clinico-pathologically distinct subtypes in sun-exposed and non-sun-exposed areas. Melanocytes are derived from multipotent neural crest cells and are present in diverse anatomical locations, including skin, eyes, and various mucosal membranes. Tissue-resident melanocyte stem cells and melanocyte precursors contribute to...

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PMID: 37132530
DOI: 10.1111/pcmr.13092

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