Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Transcriptional signatures underlying dynamic phenotypic switching and novel disease biomarkers in a linear cellular model of melanoma progression.

Neoplasia (New York, N.Y.) - 1 Apr 2021

Pessoa Diogo de Oliveira, Rius Flávia Eichemberger, Papaiz Debora D'Angelo, Ayub Ana Luísa Pedroso, Morais Alice Santana, de Souza Camila Ferreira, da Paixão Vinicius Ferreira, Setubal João Carlos, Newton-Bishop Julia, Nsengimana Jérémie, Azevedo Hatylas, Reis Eduardo Moraes, Jasiulionis Miriam Galvonas

Abstract excerpt

Despite advances in therapeutics, the progression of melanoma to metastasis still confers a poor outcome to patients. Nevertheless, there is a scarcity of biological models to understand cellular and molecular changes taking place along disease progression. Here, we characterized the transcriptome profiles of a multi-stage murine model of melanoma progression comprising a nontumorigenic melanocyte lineage...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinogenesis
Share to Cell Plasticity

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epithelial-Mesenchymal Transition

Share to Melanocytes

Share to Melanoma

Share to Neoplasm Metastasis

Share to Sequence Analysis, RNA

Share to Transcriptome

Source

Open in PubMed Open full text

Identifiers

PMID: 33845354
DOI: 10.1016/j.neo.2021.03.007
PMCID: PMC8042650

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Transcriptional signatures underlying dynamic phenotypic switching and novel disease biomarkers in a linear cellular model of melanoma progression.PMID 33845354Read ↗

Gene co-expression and histone modification signatures are associated with melanoma progression, epithelial-to-mesenchymal transition, and metastasisSemantic proximity Read ↗

Single-cell gene regulatory network analysis reveals new melanoma cell states and transition trajectories during phenotype switchingSemantic proximity Read ↗

Comprehensive Expression Profiling of Tumor Cell Lines Identifies Molecular Signatures of Melanoma ProgressionSemantic proximity Read ↗

Genetic and Genomic Pathways of Melanoma Development, Invasion and Metastasis.Semantic proximity Read ↗

Mining gene expression signature for the detection of pre-malignant melanocytes and early melanomas with risk for metastasis.Semantic proximity Read ↗

Exploring the Complex and Multifaceted Interplay between Melanoma Cells and the Tumor MicroenvironmentSemantic proximity Read ↗

Multi-modal molecular programs regulate melanoma cell stateSemantic proximity Read ↗

Cooperative behaviour and phenotype plasticity evolve during melanoma progression.Semantic proximity Read ↗

Understanding Molecular Mechanisms of Phenotype Switching and Crosstalk with TME to Reveal New Vulnerabilities of Melanoma.Semantic proximity Read ↗

The immunohistochemistry of invasive and proliferative phenotype switching in melanoma: a case report.Semantic proximity Read ↗

Multi-model preclinical platform predicts clinical response of melanoma to immunotherapySemantic proximity Read ↗

Genomic and signalling pathway characterization of the NZM panel of melanoma cell lines: A valuable model for studying the impact of genetic diversity in melanoma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.