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Article

Screening for functional transcriptional and splicing regulatory variants with GenIE.

Nucleic acids research - 16 Dec 2020

Cooper Sarah E, Schwartzentruber Jeremy, Bello Erica, Coomber Eve L, Bassett Andrew R

Abstract excerpt

Genome-wide association studies (GWAS) have identified numerous genetic loci underlying human diseases, but a fundamental challenge remains to accurately identify the underlying causal genes and variants. Here, we describe an arrayed CRISPR screening method, Genome engineering-based Interrogation of Enhancers (GenIE), which assesses the effects of defined alleles on transcription or splicing when introduced in...

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Identifiers

PMID: 33152068
DOI: 10.1093/nar/gkaa960
PMCID: PMC7736817

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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