Article

Screening for functional regulatory variants in open chromatin using GenIE-ATAC

2022-02-10

Abstract excerpt

Understanding the effects of genetic variation in gene regulatory elements is crucial to interpreting genome function. This is particularly pertinent for the hundreds of thousands of disease-associated variants identified by GWAS, which frequently sit within gene regulatory elements but whose functional effects are often unknown. Current methods are limited in their scalability and ability to assay regulatory vari...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7366b72f-5951-5984-8cda-df76a7d14074
DOI: 10.1101/2022.02.09.479775

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Screening for functional regulatory variants in open chromatin using GenIE-ATACDOI 10.1101/2022.02.09.479775Read

The architecture of allele-specific regulatory variant effects across five human genomesSemantic proximity Read

Mapping functional non-coding variation in individual human genomes through haplotyping, multiomics, and deep learning.Semantic proximity Read

A New Approach for Discovering Functional Links Connecting Non-Coding Regulatory Variants to Gene TargetsSemantic proximity Read

Large-scale identification of sequence variants influencing human transcription factor occupancy in vivo.Semantic proximity Read

ALTRE: workflow for defining ALTered Regulatory Elements using chromatin accessibility dataSemantic proximity Read

Systematic identification of human SNPs affecting regulatory element activitySemantic proximity Read

Constrained Open Chromatin Regions Reveal Functional Elements Shaping Human TraitsSemantic proximity Read

MOCHA: advanced statistical modeling of scATAC-seq data enables functional genomic inference in large human disease cohortsSemantic proximity Read

chromMAGMA: regulatory element-centric interrogation of risk variantsSemantic proximity Read

A single-cell atlas of chromatin accessibility in the human genome.Semantic proximity Read

DNA-binding factor footprints and enhancer RNAs identify functional non-coding genetic variantsSemantic proximity Read

Identifying transcription factor-bound activators and silencers in the chromatin accessible human genome using ATAC-STARR-seqSemantic proximity Read