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Article

CRISPR tiling deletion screens reveal functional enhancers and allelic compensation effects (ACE) on SIN3A transcription.

Nature communications - 25 Mar 2026

Ren Xingjie, Zheng Lina, Liu Yuxi, Maliskova Lenka, Tam Tsz Wai, Sun Yifan, Liu Hongjiang, Cui Xiekui, Lee Jerry, Takagi Maya Asami, Li Bin, Ren Bing, Wang Wei, Shen Yin

Abstract excerpt

Precise transcriptional regulation is critical for cellular function and development, yet the mechanism of this process remains poorly understood for many genes. To gain a deeper understanding of the regulation of neuropsychiatric disease risk genes, we identify a total of 39 functional enhancers for four dosage-sensitive genes, APP, FMR1, MECP2, and SIN3A, using CRISPR tiling deletion screening in human induced...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41881989
DOI: 10.1038/s41467-026-70933-y
PMCID: PMC13181091

Genes

SIN3A
ACE
APP
FMR1
MECP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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