Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The association of clinical phenotypes to known AD/FTD genetic risk loci and their inter-relationship.

PloS one - 1 Jan 2020

Li Qingqin S, Tian Chao, Hinds David, Seabrook Guy R

Abstract excerpt

To elucidate how variants in genetic risk loci previously implicated in Alzheimer's Disease (AD) and/or frontotemporal dementia (FTD) contribute to expression of disease phenotypes, a phenome-wide association study was performed in two waves. In the first wave, we explored clinical traits associated with thirteen genetic variants previously reported to be linked to disease risk using both the 23andMe and UKB...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer Disease
Share to Apolipoproteins E
Share to Frontotemporal Dementia

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Loci

Share to Genome-Wide Association Study

Share to Mendelian Randomization Analysis

Share to Quantitative Trait Loci

Share to Risk Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 33152005
DOI: 10.1371/journal.pone.0241552
PMCID: PMC7644002

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The association of clinical phenotypes to known AD/FTD genetic risk loci and their inter-relationship.PMID 33152005Read ↗

Genetic overlap between Alzheimer's disease and immune-mediated diseases: An atlas of shared genetic determinants and biological convergenceSemantic proximity Read ↗

Alzheimer's Disease Investigated via Gene-Environment Interactions, Biochemical Pathways, Cellular Processes, and Disease Phenotype VariabilitySemantic proximity Read ↗

Genetic overlap between Alzheimer's disease and immune-mediated diseases: an atlas of shared genetic determinants and biological convergence.Semantic proximity Read ↗

Genome-wide association analysis of dementia and its clinical endophenotypes reveal novel loci associated with Alzheimer’s disease and three causality networks of AD: the GR@ACE projectSemantic proximity Read ↗

Shared genetic aetiology of Alzheimer’s disease and age-related macular degeneration by APOC1 and APOE genesSemantic proximity Read ↗

Associations of Alzheimer’s disease risk variants with gene expression, amyloidosis, tauopathy, and neurodegenerationSemantic proximity Read ↗

Comprehensive adjudication identifies 111 high-confidence loci for Alzheimer's disease and related dementiasSemantic proximity Read ↗

Blood and Brain Transcriptome Analysis Reveals APOE Genotype-mediated and Immune-related Pathways Involved in Alzheimer DiseaseSemantic proximity Read ↗

Genomic characterization of Alzheimer's disease and genotype-related phenotypic analysis of biological markers in dementia.Semantic proximity Read ↗

Heterogeneous effects of genetic risk for Alzheimer's disease on the phenome.Semantic proximity Read ↗

Genetics of Late‐Onset Alzheimer′s Disease: Update from the Alzgene Database and Analysis of Shared PathwaysSemantic proximity Read ↗

Cross-phenotype associations between Alzheimer’s Disease and its comorbidities may provide clues to progressionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.