Article
HCV Genetic Diversity Can Be Used to Infer Infection Recency and Time since Infection.
Viruses - 31 Oct 2020
Carlisle Louisa A, Turk Teja, Metzner Karin J, Mbunkah Herbert A, Shah Cyril, Böni Jürg, Huber Michael, Braun Dominique L, Fehr Jan, Salazar-Vizcaya Luisa, Rauch Andri, Yerly Sabine, Nguyen Aude, Cavassini Matthias, Stoeckle Marcel, Vernazza Pietro, Bernasconi Enos, Günthard Huldrych F, Kouyos Roger D
Abstract excerpt
HIV-1 genetic diversity can be used to infer time since infection (TSI) and infection recency. We adapted this approach for HCV and identified genomic regions with informative diversity. We included 72 HCV/HIV-1 coinfected participants of the Swiss HIV Cohort Study, for whom reliable estimates of infection date and viral sequences were available. Average pairwise diversity (APD) was calculated over each codon...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.