Article
Human Immunodeficiency Virus (HIV) Genetic Diversity Informs Stage of HIV-1 Infection Among Patients Receiving Antiretroviral Therapy in Botswana.
The Journal of infectious diseases - 19 Apr 2022
Ragonnet-Cronin Manon, Golubchik Tanya, Moyo Sikhulile, Fraser Christophe, Essex Max, Novitsky Vlad, Volz Erik
Abstract excerpt
BACKGROUND: Human immunodeficiency virus (HIV)-1 genetic diversity increases during infection and can help infer the time elapsed since infection. However, the effect of antiretroviral treatment (ART) on the inference remains unknown. METHODS: Participants with estimated duration of HIV-1 infection based on repeated testing were sourced from cohorts in Botswana (n = 1944). Full-length HIV genome sequencing was...
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