Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Estimating HIV-1 Viremic Time From Reservoir Sequence Diversity With Uncertainty Quantification.

The Journal of infectious diseases - 15 May 2026

Kankaka Edward N, Tomusange Stephen, Kityamuweesi Taddeo, Quiros Gabriel, DiRico Nicholas, Capoferri Adam A, Baker Owen, Brown Erin E, Miller Jernelle, Saraf Sharada, Kirby Charles, Lynch Briana, Hackman Jada, Martens Craig, Quinn Thomas C, Scully Eileen P, Khan Amjad, Poon Art F Y, Prodger Jessica L, Galiwango Ronald M, Reynolds Steven J, Redd Andrew D

Abstract excerpt

BACKGROUND: Estimating HIV viremic time helps better understand reservoir dynamics and inform cure trials. Traditional approaches rely on serological assays or CD4 counts, which can lack precision. Sequence-based estimates using pretreatment RNA diversity help address this, but are limited by immediate ART initiation. METHODS: We developed Bayesian models to predict viremic time from diversity in HIV reservoir...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bayes Theorem
Share to HIV-1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HIV Infections

Share to Sweden

Share to Uganda

Share to Uncertainty

Share to Viral Load

Share to Viremia

Source

Open in PubMed Open full text

Identifiers

PMID: 41498757
DOI: 10.1093/infdis/jiag020
PMCID: PMC13175629

Genes

CD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Estimating HIV-1 Viremic Time From Reservoir Sequence Diversity With Uncertainty Quantification.PMID 41498757Read ↗

Estimating time of HIV-1 infection from next-generation sequence diversitySemantic proximity Read ↗

Estimating time of HIV-1 infection from next-generation sequence diversitySemantic proximity Read ↗

HCV Genetic Diversity Can Be Used to Infer Infection Recency and Time since Infection.Semantic proximity Read ↗

Use of a high resolution melting (HRM) assay to compare gag, pol, and env diversity in adults with different stages of HIV infection.Semantic proximity Read ↗

Quantitation of the latent HIV-1 reservoir from the sequence diversity in viral outgrowth assays.Semantic proximity Read ↗

Quantifying prevalence and risk factors of HIV multiple infection in Uganda from population-based deep-sequence dataSemantic proximity Read ↗

Long-Read Deep Sequencing Reveals High Rates of Multilineage Transmission and Rapid Viral Population Changes in Acute HIV InfectionSemantic proximity Read ↗

Factors influencing estimates of HIV-1 infection timing using BEAST.Semantic proximity Read ↗

HIV Proviral Burden, Genetic Diversity, and Dynamics in Viremic Controllers Who Subsequently Initiated Suppressive Antiretroviral Therapy.Semantic proximity Read ↗

Genetic Diversity From Proviral DNA as a Proxy for Time Since HIV-1 Infection.Semantic proximity Read ↗

Human Immunodeficiency Virus (HIV) Genetic Diversity Informs Stage of HIV-1 Infection Among Patients Receiving Antiretroviral Therapy in Botswana.Semantic proximity Read ↗

Analysis of Viral Diversity in Relation to the Recency of HIV-1C Infection in Botswana.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.