Article
Use of a high resolution melting (HRM) assay to compare gag, pol, and env diversity in adults with different stages of HIV infection.
PloS one - 1 Jan 2011
Cousins Matthew M, Laeyendecker Oliver, Beauchamp Geetha, Brookmeyer Ronald, Towler William I, Hudelson Sarah E, Khaki Leila, Koblin Beryl, Chesney Margaret, Moore Richard D, Kelen Gabor D, Coates Thomas, Celum Connie, Buchbinder Susan P, Seage George R, Quinn Thomas C, Donnell Deborah, Eshleman Susan H
Abstract excerpt
BACKGROUND: Cross-sectional assessment of HIV incidence relies on laboratory methods to discriminate between recent and non-recent HIV infection. Because HIV diversifies over time in infected individuals, HIV diversity may serve as a biomarker for assessing HIV incidence. We used a high resolution melting (HRM) diversity assay to compare HIV diversity in adults with different stages of HIV infection. This assay...
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