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Article

Genetic Diversity From Proviral DNA as a Proxy for Time Since HIV-1 Infection.

The Journal of infectious diseases - 23 Sept 2024

Zeeb Marius, Frischknecht Paul, Huber Michael, Schenkel Corinne D, Neumann Kathrin, Leeman Christine, Notter Julia, Rauch Andri, Stöckle Marcel, Cavassini Matthias, Bernasconi Enos, Braun Dominique L, Günthard Huldrych F, Metzner Karin J, Kouyos Roger D

Abstract excerpt

HIV-1 RNA genetic diversity predicts time since infection, which is important for clinical care and research. It is unclear, however, whether proviral DNA genetic diversity sampled under suppressive antiretroviral therapy can be used for this purpose. We tested whether proviral genetic diversity from next-generation sequencing predicts time since infection and recency in 221 people with HIV-1 with known infection...

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Share to DNA, Viral
Share to High-Throughput Nucleotide Sequencing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HIV Infections

Share to Proviruses

Share to RNA, Viral

Share to Time Factors

Share to Viral Load

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Identifiers

PMID: 38507572
DOI: 10.1093/infdis/jiae149
PMCID: PMC11420808

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