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Article

A genome-scale analysis for identification of genes required for growth or survival of Haemophilus influenzae.

Proceedings of the National Academy of Sciences of the United States of America - 22 Jan 2002

Akerley Brian J, Rubin Eric J, Novick Veronica L, Amaya Kensey, Judson Nicholas, Mekalanos John J

Abstract excerpt

A high-density transposon mutagenesis strategy was applied to the Haemophilus influenzae genome to identify genes required for growth or viability. This analysis detected putative essential roles for the products of 259 ORFs of unknown function. Comparisons between complete genomes defined a subset of these proteins in H. influenzae having homologs in Mycobacterium tuberculosis that are absent in Saccharomyces...

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Identifiers

PMID: 11805338
DOI: 10.1073/pnas.012602299
PMCID: PMC117414

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