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Article

Essential genes of a minimal bacterium.

Proceedings of the National Academy of Sciences of the United States of America - 10 Jan 2006

Glass John I, Assad-Garcia Nacyra, Alperovich Nina, Yooseph Shibu, Lewis Matthew R, Maruf Mahir, Hutchison Clyde A, Smith Hamilton O, Venter J Craig

Abstract excerpt

Mycoplasma genitalium has the smallest genome of any organism that can be grown in pure culture. It has a minimal metabolism and little genomic redundancy. Consequently, its genome is expected to be a close approximation to the minimal set of genes needed to sustain bacterial life. Using global transposon mutagenesis, we isolated and characterized gene disruption mutants for 100 different nonessential...

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Identifiers

PMID: 16407165
DOI: 10.1073/pnas.0510013103
PMCID: PMC1324956

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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