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Article

Genome-wide detection of genes targeted by non-Ig somatic hypermutation in lymphoma.

PloS one - 1 Jan 2012

Jiang Yanwen, Soong T David, Wang Ling, Melnick Ari M, Elemento Olivier

Abstract excerpt

The processes of somatic hypermutation (SHM) and class switch recombination introduced by activation-induced cytosine deaminase (AICDA) at the Immunoglobulin (Ig) loci are key steps for creating a pool of diversified antibodies in germinal center B cells (GCBs). Unfortunately, AICDA can also accidentally introduce mutations at bystander loci, particularly within the 5' regulatory regions of proto-oncogenes...

Read the complete abstract on PubMed

Topics

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Share to Chromatin Immunoprecipitation
Share to Genes, Neoplasm
Share to Genes, Regulator

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Lymphoma

Share to Lymphoma, Large B-Cell, Diffuse

Share to Methylation

Share to Somatic Hypermutation, Immunoglobulin

Source

Open in PubMed Open full text

Identifiers

PMID: 22808135
DOI: 10.1371/journal.pone.0040332
PMCID: PMC3395700

Genes

AICDA
BACH2
BCL6
BTG2
CIITA
CXCR4
EBF1
PIM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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