Article
Identification of a Metabolic, Transcriptomic, and Molecular Signature of Patatin-Like Phospholipase Domain Containing 3-Mediated Acceleration of Steatohepatitis.
Hepatology (Baltimore, Md.) - 1 Apr 2021
Banini Bubu A, Kumar Divya P, Cazanave Sophie, Seneshaw Mulugeta, Mirshahi Faridoddin, Santhekadur Prasanna K, Wang Liangsu, Guan Hong Ping, Oseini Abdul M, Alonso Cristina, Bedossa Pierre, Koduru Srinivas V, Min Hae-Ki, Sanyal Arun J
Abstract excerpt
BACKGROUND AND AIMS: The mechanisms by which the I148M mutant variant of the patatin-like phospholipase domain-containing 3 (PNPLA3I148M ) drives development of nonalcoholic steatohepatitis (NASH) are not known. The aim of this study was to obtain insights on mechanisms underlying PNPLA3I148M -induced acceleration of NASH. APPROACH AND RESULTS: Hepatocyte-specific overexpression of empty vector (luciferase),...
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