Article

The fatty liver disease-causing protein PNPLA3-I148M alters lipid droplet-Golgi dynamics

2023-10-14

Abstract excerpt

Non-alcoholic fatty liver disease (NAFLD), recently renamed metabolic dysfunction-associated steatotic liver disease (MASLD), is a progressive metabolic disorder that begins with aberrant triglyceride accumulation in the liver and can lead to cirrhosis and cancer. A common variant in the gene PNPLA3 , encoding the protein PNPLA3-I148M, is the strongest known genetic risk factor for MASLD to date. Despite its disc...

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Literature Corpus work: 5fdbef42-b2e2-53b8-bd54-e67e38c89b0a
DOI: 10.1101/2023.10.13.562302

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