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PNPLA3—A Potential Therapeutic Target for Personalized Treatment of Chronic Liver Disease

17 Dec 2019

Abstract excerpt

Patatin-like phospholipase domain-containing protein 3 (PNPLA3) is a lipid droplet-associated protein that has been shown to have hydrolase activity toward triglycerides and retinyl esters. The first evidence of PNPLA3 being associated with fatty liver disease was revealed by a genome-wide association study (GWAS) of Hispanic, African American, and European American individuals in the Dallas Heart Study back in...

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Diet, Metabolism, and Disease
Lipid metabolism and biosynthesis
Liver Disease Diagnosis and Treatment

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 31921875
DOI: 10.3389/fmed.2019.00304

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