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The PNPLA3 variant I148M reveals protective effects toward hepatocellular carcinoma in mice via restoration of omega-3 polyunsaturated fats.

The Journal of nutritional biochemistry - 1 Oct 2022

Patsenker Eleonora, Thangapandi Veera Raghavan, Knittelfelder Oskar, Palladini Alessandra, Hefti Michaela, Beil-Wagner Jane, Rogler Gerhard, Buch Thorsten, Shevchenko Andrej, Hampe Jochen, Stickel Felix

Abstract excerpt

Alcohol consumption and high caloric diet are leading causes of progressive fatty liver disease. Genetic variant rs738409 in patatin-like phospholipase domain-containing protein 3 (PNPLA3 rs738409 C>G) has been repeatedly described as one of the major risk loci for alcoholic liver cirrhosis (ALC) and hepatocellular carcinoma (HCC) in humans, however, the mechanism behind this association is incompletely...

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PMID: 35691594
DOI: 10.1016/j.jnutbio.2022.109081

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The PNPLA3 variant I148M reveals protective effects toward hepatocellular carcinoma in mice via restoration of omega-3 polyunsaturated fats.PMID 35691594Read ↗

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PNPLA3 as a therapeutic target for fatty liver disease: the evidence to date.Semantic proximity Read ↗

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Substrate-Specific Function of PNPLA3 Facilitates Hepatic VLDL-Triglyceride Secretion During Stimulated LipogenesisSemantic proximity Read ↗

PSD3 downregulation confers protection against fatty liver disease.Semantic proximity Read ↗

PNPLA3-associated steatohepatitis: toward a gene-based classification of fatty liver disease.Semantic proximity Read ↗

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