Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Novel, clinically relevant genomic patterns identified by comprehensive genomic profiling in ATRX-deficient IDH-wildtype adult high-grade gliomas.

Scientific reports - 27 Oct 2023

Bedics Gábor, Szőke Péter, Bátai Bence, Nagy Tibor, Papp Gergő, Kránitz Noémi, Rajnai Hajnalka, Reiniger Lilla, Bödör Csaba, Scheich Bálint

Abstract excerpt

Glioblastomas are the most common IDH-wildtype adult high-grade gliomas, frequently harboring mutations in the TERT gene promoter (pTERT) and utilizing the subsequent telomerase overexpression for telomere length maintenance. However, some rare cases show loss of ATRX and use alternative mechanisms of telomere lengthening. In this study, we performed the first complex genomic analysis specifically concentrating...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Brain Neoplasms
Share to Genomics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glioblastoma

Share to Glioma

Share to Isocitrate Dehydrogenase

Share to Mutation

Share to Telomere Homeostasis

Share to X-linked Nuclear Protein

Source

Open in PubMed Open full text

Identifiers

PMID: 37891325
DOI: 10.1038/s41598-023-45786-w
PMCID: PMC10611758

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Novel, clinically relevant genomic patterns identified by comprehensive genomic profiling in ATRX-deficient IDH-wildtype adult high-grade gliomas.PMID 37891325Read ↗

Functional Assessment of ATRX Alterations Improves Glioma DiagnosisSemantic proximity Read ↗

Functional analysis of telomere maintenance mechanisms is more informative than immunohistochemistry for ATRX mutation interpretation in Gliomas.Semantic proximity Read ↗

The genomic landscape of TERT promoter wildtype-IDH wildtype glioblastoma.Semantic proximity Read ↗

Frequent ATRX, CIC, FUBP1 and IDH1 mutations refine the classification of malignant gliomas.Semantic proximity Read ↗

Mutant IDH1 Cooperates with ATRX Loss to Drive the Alternative Lengthening of Telomere Phenotype in Glioma.Semantic proximity Read ↗

Whole-exome sequencing identifies ATRX mutation as a key molecular determinant in lower-grade glioma.Semantic proximity Read ↗

ALT in Pediatric High-Grade Gliomas Can Occur without <i>ATRX</i> Mutation and is Enriched in Patients with Pathogenic Germline MMR VariantsSemantic proximity Read ↗

New Molecular Considerations for Glioma: IDH, ATRX, BRAF, TERT, H3 K27M.Semantic proximity Read ↗

The Role of ATRX in Glioma BiologySemantic proximity Read ↗

Mutant ATRX: uncovering a new therapeutic target for glioma.Semantic proximity Read ↗

Omics-based integrated analysis identified ATRX as a biomarker associated with glioma diagnosis and prognosisSemantic proximity Read ↗

ATRX mRNA expression combined with IDH1/2 mutational status and Ki-67 expression refines the molecular classification of astrocytic tumors: evidence from the whole transcriptome sequencing of 169 samples samples.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.