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Article

First Demonstration of Double Dissociation between COMT-Met158 and COMT-Val158 Cognitive Performance When Stressed and When Calmer.

Cerebral cortex (New York, N.Y. : 1991) - 5 Feb 2021

Zareyan Shahab, Zhang Haolu, Wang Juelu, Song Weihong, Hampson Elizabeth, Abbott David, Diamond Adele

Abstract excerpt

We present here the first evidence of the much-predicted double dissociation between the effect of stress on cognitive skills [executive functions (EFs)] dependent on prefrontal cortex (PFC) by catechol-O-methyltransferase (COMT) genotype. The COMT gene polymorphism with methionine (Met) at codon 158 results in more dopamine (DA) in PFC and generally better EFs, while with valine (Val) at codon 158 the result is...

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Identifiers

PMID: 33124661
DOI: 10.1093/cercor/bhaa276
PMCID: PMC8599760

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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