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Article

COMT Val158Met genotype selectively alters prefrontal [18F]fallypride displacement and subjective feelings of stress in response to a psychosocial stress challenge.

PloS one - 1 Jan 2013

Hernaus Dennis, Collip Dina, Lataster Johan, Ceccarini Jenny, Kenis Gunther, Booij Linda, Pruessner Jens, Van Laere Koen, van Winkel Ruud, van Os Jim, Myin-Germeys Inez

Abstract excerpt

Catechol-O-methyltransferase (COMT) plays an essential role in degradation of extracellular dopamine in prefrontal regions of the brain. Although a polymorphism in this gene, COMT Val(158)Met, affects human behavior in response to stress little is known about its effect on dopaminergic activity associated with the human stress response, which may be of interest for stress-related psychiatric disorders such as...

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PMID: 23799032
DOI: 10.1371/journal.pone.0065662
PMCID: PMC3683024

Genes

COMT

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